Macrophages and cancer

The uncontrolled growth of metastases resistant to conventional therapeutic modalities is a major cause of death from cancer. Unlike most populations of tumor-associated macrophages that possess pro-tumor and immunosuppressive properties (Biswas and Mantovani, 2010), macrophages in human colorectal cancer have been found to be functionally (and phenotypically) anti-tumor (Edin et al., 2012, Ong et al., 2012, Zhang et al., 2014). Macrophages are a major component of the tumor microenvironment and orchestrate various aspects of immunity. Interestingly, diet plays a role in determining the type of macrophage likely to be activated. Whitworth PW(1), Pak CC, Esgro J, Kleinerman ES, Fidler IJ.

The human immune system is responsible for identifying, destroying, and removing all foreign substances from the body. It is driven not only by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between cancer cells and their altered microenvironment components. Here, we discovered the different macrophages’ impacts on lung cancer … In one meta-analysis it has been reported that over 80% of studies show a correlation between macrophage density and poor patient prognosis (Bingle et al., 2002) and recent studies have further supported this conclusion.For example, there is a strong association between … Macrophages play a complex role in tumor progression since they can exert both tumor-preventing (M1 macrophages) and tumor-promoting (M2 macrophages) activities. Tumor metastasis is a major contributor to the death of cancer patients. J. Immunol. The characteristic of TAM is largely dependent on the stimuli present in its tumour microenvironment (TME). In cancer, macrophages can both increase and decrease tumor growth depending upon the type of tumor and type of macrophage involved. Macrophages and Cancer.
Introduction. During cancer progression, malignant cells hijack macrophages in a process that has not yet been fully explored.

Macrophages are better able to resist infection by HIV-1 than CD4+ T cells, although susceptibility to HIV infection differs among macrophage subtypes. In cancer, macrophages can both increase and decrease tumor growth depending upon the type of tumor and type of macrophage involved. Author information: (1)Department of Cell Biology, University of Texas M.D. Blood circulates through the body in the arteries and veins. Tumor-associated macrophages (TAM) have served as a paradigm for cancer promoting inflammation.

Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) are important components of the tumor microenvironment, which have … Anderson Cancer Center, Houston. Macrophages in a tumor microenvironment have been characterized as M1- and M2-polarized subtypes.
Tumor-associated macrophages orchestrate various aspects of cancer, including: diversion and skewing of adaptive responses; cell growth; angiogenesis; matrix deposition and remodelling; the construction of a metastatic niche and actual metastasis; response to hormones and chemotherapeutic agents.

Macrophages can contribute to tumor growth and progression by promoting tumor cell proliferation and invasion, fostering tumor angiogenesis and suppressing antitumor immune cells. It plays an important role in determining the progression and metastasis of a tumour. In this commentary, we focus on specific signaling aspects that are related to tumor associated macrophages and their pro- or anti-tumor activities. In this context, tumor-associated macrophages (TAMs) represent key regulators of the complex interplay between the immune system and cancer.

We discuss evidence indicating that in many settings TAMs fuel, rather than limit, tumor progression, and negatively impact on responses to therapy. Cancer. CXCL12-driven stimulation of cancer cells and macrophages may elicit and reinforce a GM-CSF/HB-EGF paracrine loop, whereby macrophages contribute to cancer survival and expansion. Tumour-associated macrophage (TAM) serves as the site in which most inflammatory cells coreside. Eur. Macrophages and cancer.

Clinical studies make a strong case that macrophages promote tumorigenesis.
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