Natural killer (NK) cells are a type of lymphocyte circulating in peripheral blood named because of their effector functions in killing target cells. Natural Killer Cells. Uterine natural killer cells (uNK cells) Granulated cells have been identified in the endometrium of many species.
This set of NK cells is known as uterine natural killer (uNK) cells. Little is known about the role of natural killer (NK) cells in the uterine microenvironment. Uterine natural killer cell activity can be directly modulated through interactions with decidual stromal cells, uterine leukocytes, and invasive trophoblast. Of these, the regulation of uNK cell function by trophoblast has been particularly well explored, owing to the association between certain KIR/HLA interactions and disorders of pregnancy. They are known as “Natural Killer cells” or NK cells. Numerous decidual natural killer cells are found at the maternal-fetal interface in the placenta during early pregnancy. Natural killer cells are a diverse group of cells that can be found in the blood and other areas of the body including the uterus. Immune cells that share similar phenotypic characteristics but are poor killers populate the uterine lining at implantation and during early pregnancy when the placenta is established. While most previously studied NK cells were derived from the mouse spleen and circulate in the blood, recently others and we found tissue-resident NK (trNK) cells in many tissues that resemble group 1 ILCs (ILC1s). identified a transcription factor called PBX1, which is present in these natural killer cells and stimulates the production of growth-promoting factors, proteins needed for fetal growth and development. Natural killer cells, also known as NK cells or large granular lymphocytes (LGL), are a type of cytotoxic lymphocyte critical to the innate immune system.The role of NK cells is analogous to that of cytotoxic T cells in the vertebrate adaptive immune response.NK cells provide rapid responses to virus-infected cells, acting at around 3 days after infection, and respond to tumor formation. The major functions of a prescribed herbal formula are to prevent miscarriage, to increase circulation into the uterine lining to assist implantation, and to help reduce inflammation – the problems caused by NK cells. In the blood there are immune cells called lymphocytes. Some researchers refer to the natural killer cells which are localized to the endometrium before pregnancy as “endometrial NK cells (eNK)” and “decidual NK cells (dNK)” after decidualization ( Manaster and Mandelboim, 2008 ). Natural killer cells, also known as NK cells or large granular lymphocytes (LGL), are a type of cytotoxic lymphocyte critical to the innate immune system.